GPCRs
are a large group of cell surface receptors that have an important
role in pharmacology in present times. GPCRs or G-protein-coupled
receptors have wide-ranging functions in the human body. GPCRs
comprise cell surface receptors that respond to an extensive
assortment of external stimuli and have a crucial purpose in cell
communication. GPCRs are the target for almost 30% of drugs that are
on the market as well as the drugs that are presently being
developed.
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The
GPCRs market is anticipated to expand at an encouraging CAGR of 8.8%
to reach a total value of US$3,533.4 million by 2022. The key causes
for growth of the global GPCRs market are the mounting demand for a
variety of GPCRs assays related to drug development and the
proliferation of respiratory, cardiovascular, nervous system, and
reproductive disorders all over the world.
HPS
and Drug Discovery Platforms Need Drives Demand for cAMP Assay
The
category segmentation for GPCRs market is based on six assay types.
These are GTPγS binding assays, cAMP assays, receptor
internalization assays, reporter gene assays, GTPγS binding assays,
and calcium level detection assays. Increasing demand for cAMP assays
used in major drug discovery platforms and high throughput screening
(HTS) has led to this segment occupying the largest GPCRs market
share of 32.5% in 2013. cAMP assays are also used in a variety of
drug discovery platforms and range of therapeutic applications, so
market growth for this segment can be attributed to demand from these
related applications as well. The growth of this segment is expected
to continue over the next few years. The cAMP segment was followed by
the segment for calcium level detection assays with the second
highest market share of the GPCRs market in 2013.
Precision
as well as linearity, large signal to background ratio, and wide
sensitivity offered by such assays are among the growth factors for
assay systems. The reporter gene assay segment is also expected to
record significant growth during the coming years.
Oncology
Segment Leads Demand from GPCRs Market due to Prevalence of Cancer
The
global GPCRs market has seven categories based on therapeutic area.
These include the central nervous system (CNS), the cardiovascular
system, the immune system, the reproductive system, the respiratory
system, oncology, and others (urinary, orthopedics, abdominal). Among
these segments, oncology occupied the largest market share in terms
of revenue in the global GPCRs market in 2013. Oncology is inclusive
of numerous cancer therapy areas such as lung cancer, prostate
cancer, leukemia, cervical cancer, and numerous other malignant
tumors. The oncology segment is expected to grow substantially over
the next few years in the GPCRS market owing to the high occurrence
of several types of cancers.
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Among
the segments based on geographical regions, North America accounts
for the largest market share of the GPCRS market, due to high
awareness about advanced assays, financial ability of consumers to
buy innovative products, and high investment in healthcare
development. The North American GPCRS market is expected to continue
growing due to demand for therapeutics against obesity-related
illnesses and the growing geriatric population, which is more
susceptible to chronic diseases.
The
major players in the GPCRs market are Becton, Thermo Fisher
Scientific, Promega Corporation, Enzo Life Sciences, Inc., and
Sigma-Aldrich Corporation.
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